Current projects
UNKNOWn genes |
When the genomic sequence of the model eukaryote Saccharomyces cerevisiae (Baker’s or Brewer’s yeast) was completed in 1996, the expectation was that an understanding of the integrated functioning of the collection of genes in this single-celled eukaryote would shortly follow. Despite almost 20 years of intense collaborative effort among yeast researchers, nearly 10% of open reading frames (ORFs) are considered uncharacterized (ORFans). The goal of the Yeast ORFan Gene Project is to organize a consortium of undergraduate researchers and faculty at primarily undergraduate institutions (PUIs) to coordinate resources and design strategies to assign molecular functions to S. cerevisiae ORFans.
www.yeastorfanproject.com/ |
host factors regulating ty1 transposition |
Saccharomyces cerevisiae, or Baker’s yeast, is host to the Ty1 retroelement, which is functionally similar to human viruses such as the Human Immunodeficiency Virus (HIV). Many host cell proteins control the expression of the retroelement. We are using genetic screenings to identify yeast proteins that regulate the Ty1 retroelement.
|